Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil

Temperature and magnetism bi-responsive molecularly imprinted polymers (TMMIPs) were prepared, which showed excellent magnetic properties, thermo-sensitivity, drug-loading and recognition ability towards 5-fluorouracil (5-FU). Adsorption mechanisms were explored by using a computational analysis to simulate the imprinted site towards 5-FU. The electrostatic potential charges and population analysis results suggested that TMMIPs can be the selective sorbent of 5-FU, because of the obvious affinity between the imprinted site and 5-FU.220