کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7868223 1509160 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genipin-modified gelatin nanocarriers as swelling controlled drug delivery system for in vitro release of cytarabine
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Genipin-modified gelatin nanocarriers as swelling controlled drug delivery system for in vitro release of cytarabine
چکیده انگلیسی
The aim of the present investigation was to design biocompatible gelatin nanoparticles, capable of releasing the cytarabine drug in a controllable way by regulating the extent of swelling of nanoparticles. In order to achieve the proposed objectives, gelatin (Type A, derived from acid cured tissue) was modified by crosslinking with genipin and nanoparticles of crosslinked gelatin were prepared using single water in oil (W/O) emulsion technique. The nanoparticles were characterized by techniques like FTIR, SEM, TEM, particles size analysis, and surface potential measurements. The nanoparticle chemical architecture was found to influence drug-releasing capacity. The influence of experimental conditions such as pH and simulated physiological fluids as the release medium was also investigated on the release profiles of cytarabine. It is possible to fabricate high-performance materials, by designing of controlled size gelatin nanoparticles with good biocompatible properties along with desired drug release profiles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 61, 1 April 2016, Pages 457-465
نویسندگان
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