کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7868258 | 1509162 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diffusion in and around alginate and chitosan films with embedded sub-millimeter voids
ترجمه فارسی عنوان
اشباع در فیلم های آلژینات و کیتوزان و در اطراف آن با اطراف حفره های چند میلیمتری تعبیه شده است
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کلمات کلیدی
ژل، داربست، نفوذ، رهایی، حباب،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Hydrogel scaffolds from biopolymers have potential use in the controlled release of drugs, and as 3-D structure for the formation of tissue matrix. This article describes the solute release behavior of alginate and chitosan films with embedded voids of sub-millimeter dimensions. Nitrogen gas was bubbled in a fluidic arrangement to generate bubbles, prior to the crosslinking. The crosslinked gel was dried in a vacuum oven, and subsequently, soaked in Vitamin B-12 solution. The dimensions of the voids immediately after the cross-linking of gel, and also after complete drying were obtained using a digital microscope and scanning electron microscope respectively. The porosity of the gel was measured gravimetrically. The release of Vitamin B-12 in PBS buffer on a shaker was studied. The release experiments were repeated at an elevated temperature of 37 °C in the presence of lysozyme. The diffusion coefficient within the gel layer and the mass transfer coefficient at the interface with the bulk-liquid were estimated using a mathematical model. For comparison, the experiment was repeated with a film that does not have any embedded void. The enhancement in diffusion coefficient due to the presence of voids is discussed in this article.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 59, 1 February 2016, Pages 61-69
Journal: Materials Science and Engineering: C - Volume 59, 1 February 2016, Pages 61-69
نویسندگان
Subhajit Patra, Dharmendra Kumar Bal, Somenath Ganguly,