کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7868540 | 1509160 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vivo comparative study of tissue reaction to bare and antimicrobial polymer coated transcutaneous implants
ترجمه فارسی عنوان
در مقایسه با مقایسه واکنش بافت به داخل پروتزهای پوستی و لایه بردار پلیمری ضد میکروبی مقایسه شد
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
We coated transcutaneous implants made of titanium alloy Ti6Al4V with copolymer dimethyl (2-methacryloyloxy-ethyl) phosphonate and 4-vinylpyridine and investigated the tissue reaction with respect to its biocompatible and antimicrobial properties in vivo. We distinguished between clinically observable superficial inflammations and histologically detectable deep infections. The vinylpyridine moieties were transferred into cationic pyridinium groups by reaction with hexyl bromide. Thus polymers with both antimicrobial capacity and good biocompatibility were obtained. In a short-term study, we implanted specially designed bare or coated implants in hairless but immunocompetent mice and analyzed the tissue reaction histologically. No difference was found between bare and coated implants in the initial healing phase of up to 14Â days; however, after 21Â days the scar tissue formation was higher in the bare implant group. The degree of epithelial downgrowth was comparable in both groups at any time point. In a long-term study of up to 168Â days, we analyzed resistance to infection. In the bare implant group, 7 of the 12 implantation sites became infected deep whereas in the coated implant group only two deep infections were observed. The other implantation sites showed only superficial signs of inflammation. These results generally accord with previous in-vitro studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 61, 1 April 2016, Pages 712-719
Journal: Materials Science and Engineering: C - Volume 61, 1 April 2016, Pages 712-719
نویسندگان
Tilman Calliess, Ivonne Bartsch, Maike Haupt, Mattias Reebmann, Michael Schwarze, Meike Stiesch, Cornelia Pfaffenroth, Magda Sluszniak, Wibke Dempwolf, Henning Menzel, Frank Witte, Elmar Willbold,