کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7869472 1509169 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of oscillatory mechanical stimulation on osteoblast attachment and proliferation
ترجمه فارسی عنوان
اثر تحریک مکانیکی نوسان بر دلبستگی و تکثیر استئوآبلاست
کلمات کلیدی
تحریک مکانیکی، استئوبلاست ها، ضمیمه، ترویج شیکر مدار، استرس برشی،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
The aim of this paper is to investigate the effect of the magnitude and duration of oscillatory mechanical stimulation on osteoblast attachment and proliferation as well as the time gap between seeding and applying the stimulation. Cells were exposed to three levels of speed at two different conditions. For the first group, mechanical shear stress was applied after 20 min of cell seeding. For the second group there was no time gap between cell seeding and applying mechanical stimulation. The total area subjected to shear stress was divided into three parts and for each part a comparative study was conducted at defined time points. Our results showed that both shear stress magnitude and the time gap between cell seeding and applying shear stress, are important in further cell proliferation and attachment. The effect of shear stress was not significant at lower speeds for both groups at earlier time points. However, a higher percentage of area was covered by cells at later time points under shear stress. In addition, the time gap can also improve osteoblast attachment. For the best rate of cell attachment and proliferation, the magnitude of shear stress and time gap should be optimized. The results of this paper can be utilized to improve cell attachment and proliferation in bioreactors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 52, 1 July 2015, Pages 129-134
نویسندگان
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