کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7924972 | 1512497 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An interferometric optical fiber biosensor with high sensitivity for IgG/anti-IgG immunosensing
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
مواد الکترونیکی، نوری و مغناطیسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An immunosensor with low detection limit for detecting human-IgG (IgG, immunoglobulin G) is presented in this work. The sensor was designed using single mode fiber with large core-offset fusion splice based on Mach-Zehnder interferometer (MZI). The refractive index (RI) sensitivity is as high as 13936 nm/RIU in the RI range of 1.3328-1.3398, and the resolution of 1.44Ã10â6 is obtained. Afterwards, the sensing surface was immobilized with staphylococcal protein A and goat anti-human IgG to detect different concentrations of human-IgG, and a low detection limit of 47 ng/ml was observed. The proposed immunosensor has advantages of far simpler fabrication, high sensitivity, low detection limit, reusability and have promising potential for detecting small refractive index change in biological samples and application in biomedical field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Optics Communications - Volume 426, 1 November 2018, Pages 388-394
Journal: Optics Communications - Volume 426, 1 November 2018, Pages 388-394
نویسندگان
Bo-Tao Wang, Qi Wang,