Application of MBG as a coating material on mechanically stronger but less degradable ceramic scaffolds for enhanced osteogenesis

Improving the mechanical properties and maintaining the desired degradability of the bioceramic scaffold is always being a contradiction in the field of bone tissue engineering. To resolve this conflict, highly degradable mesoporous bioactive glass (MBG) was homogenously coated on the mechanically stronger hardystonite (Ca2ZnSi2O7, HT) scaffolds. The presence of MBG on the scaffold covers the shortage of the bioactive ions released from the underlying HT scaffold in the initial stage and provides a better platform for cellular adhesion. Results proved that the HT scaffold coated with MBG (HT/M) exhibited appealing biological properties, pointing out their potential application in bone tissue engineering.