کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8021176 | 1517271 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of monodisperse biodegradable magnetic microspheres using a T-shaped microchannel reactor
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation of monodisperse biodegradable magnetic microspheres using a T-shaped microchannel reactor Preparation of monodisperse biodegradable magnetic microspheres using a T-shaped microchannel reactor](/preview/png/8021176.png)
چکیده انگلیسی
Monodisperse magnetic microspheres with biodegradability and biocompatibility were successfully prepared using a T-shaped microchannel reactor instead of the traditional three-necked flask equipped with the mechanical stirrer. Solvothermal was adopted to produce hydrophilic ferriferrous oxide (Fe3O4) nanoparticles with high magnetic responsiveness, which was subsequently emulsified with a dichloromethane solution of polylactic acid (PLA) in the presence of a gelatin stabilizer. This water-in-oil (W/O) emulsion and an additional aqueous phase, namely an aqueous polyvinyl alcohol (PVA) solution, were injected into the T-shaped microchannel reactor and converged at the joint to yield a W/O/W composite emulsion. Evaporation of the solvent in the microchannel gave rise to the target magnetic microspheres. The results show that the magnetic microspheres have a uniform particle size and good magnetic responsiveness, indicating their potential use in targeted drug delivery for cancer treatment and thermotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 117, 15 February 2014, Pages 37-40
Journal: Materials Letters - Volume 117, 15 February 2014, Pages 37-40
نویسندگان
Peng Liu, Yi Zhong, Yan Luo,