کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8045881 1519028 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adsorption and characterization of palygorskite-isoniazid nanohybrids
ترجمه فارسی عنوان
جذب و خصوصی سازی نانویایبریدهای لیگورسکتی-ایسونزیید
موضوعات مرتبط
مهندسی و علوم پایه علوم زمین و سیارات ژئوشیمی و پترولوژی
چکیده انگلیسی
Studies of the equilibrium and thermodynamic aspects of the adsorption of isoniazid onto a pharmaceutical-grade palygorskite and features of the resultant clay drug nanohybrid systems were carried out. Equilibrium studies were performed in aqueous medium at different times and temperatures. The overall adsorption process was explained as the result of two simple processes: drug adsorption on the activated sites of palygorskite and a slight precipitation phase of drug molecules over the adsorbed monolayer. Formation of the nanohybrid was spontaneous, exothermic and exoentropic, obtaining an increase in the thermodynamic stability of the system (ΔH = − 48,82 kJ/mol; ΔS = − 0.14 kJ/mol K). A full and comprehensive study of the solid state characterization corroborated the effective interaction between the components. Total amount of INH loaded was about 20% w/w. FTIR spectra revealed the interaction via water bridges between the endocyclic N of the drug and surface OH groups of palygorskite. Surface charge studies confirmed the non-electrostatic nature of the interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Clay Science - Volume 160, August 2018, Pages 180-185
نویسندگان
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