Tsunami hazard in the southeast Aegean Sea

► We assess earthquake-generated tsunami hazard for the Greek island of Rhodes. ► Numerical hydrodynamic generation-to-inundation simulations with MOST. ► Near-field worst case scenarios associated with seismic events of magnitude 8.0-8.4. ► Statistical approach associated with seismic sources with spatial uncertainty. ► Probabilistic results might feature higher impact than single worst-case scenarios.