کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8149153 1524349 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Steering a crystallization process to reduce crystal polydispersity; case study of insulin crystallization
ترجمه فارسی عنوان
فرایند کریستالیزه کردن برای کاهش پلییدریزی شدن کریستال مطالعه موردی کریستالسیون انسولین
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی
The use of the classical nucleation-growth-separation principle (NGSP) was restricted hitherto to nucleation kinetics studies only. A novel application of the NGSP is proposed. To reduce crystal polydispersity internal seeding of equally-sized crystals is suggested, the advantage being avoidance of crystal grinding, sieving and any introduction of impurities. In the present study, size distributions of grown insulin crystals are interpreted retrospectively to select the proper nucleation stage parameters. The conclusion is that when steering a crystallization process aimed at reducing crystal polydispersity, the shortest possible nucleation stage duration has to be chosen because it renders the closest size distribution of the nucleated crystal seeds. Causes of inherent propensity to increasing crystal polydispersity during prolonged growth are also explored. Step sources of increased activity, present in some crystals while absent in others, are pointed as the major polydispersity cause. Insulin crystal morphology is also considered since it determines the dissolution rate of a crystalline medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 480, 15 December 2017, Pages 164-169
نویسندگان
, ,