کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8209587 | 1532091 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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![عکس صفحه اول مقاله: Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS](/preview/png/8209587.png)
چکیده انگلیسی
Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 106, December 2015, Pages 195-201
Journal: Applied Radiation and Isotopes - Volume 106, December 2015, Pages 195-201
نویسندگان
Tooru Andoh, Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Yoshinori Sakurai, Hiroki Tanaka, Ikuo Fujita, Naomasa Fukase, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Hiroshi Sasai, Teruya Kawamoto, Mitsunori Kirihata, Yoshinobu Fukumori,