کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8209665 | 1532099 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation dosimetry estimation of N-(2-[18F]fluoropropionyl)- l-glutamate based on the mice distribution data
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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![عکس صفحه اول مقاله: Radiation dosimetry estimation of N-(2-[18F]fluoropropionyl)- l-glutamate based on the mice distribution data Radiation dosimetry estimation of N-(2-[18F]fluoropropionyl)- l-glutamate based on the mice distribution data](/preview/png/8209665.png)
چکیده انگلیسی
N-(2-[18F]fluoropropionyl)-l-glutamate([18F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography-computer tomography (PET-CT). The absorbed and effective radiation doses resulting from the intravenous administration of [18F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [18F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4 μGy/MBq, the brain received the lowest dose, 5.5 μGy/MBq, and other organs received doses in the range of 8.3-11.9 μGy/MBq. The effective dose was 17.0 μSv/MBq. The data show that a 370 MBq (10 mCi) injection of [18F]FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 98, April 2015, Pages 108-112
Journal: Applied Radiation and Isotopes - Volume 98, April 2015, Pages 108-112
نویسندگان
Caihua Tang, Zeqing Xu, Kongzhen Hu, Baoguo Yao, Ganghua Tang, Dahong Nie,