Prognostic Significance of Tumor Hypoxia Inducible Factor-1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer

There are significant differences in radiation therapy outcome within a homogeneous subsite of the oropharynx related to molecular marker expression. The work highlights the importance of studying homogeneous groups of patients in HNSCC, and the complex interrelationships between tumor biology and clinicopathologic factors. The establishment of tumor-type specific markers would represent a major advance in this area.