کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8247496 | 1533180 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combining radiotherapy and angiogenesis inhibitors: Clinical trial design
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Combining radiotherapy and angiogenesis inhibitors: Clinical trial design Combining radiotherapy and angiogenesis inhibitors: Clinical trial design](/preview/png/8247496.png)
چکیده انگلیسی
Radiotherapy (RT) plays a vital role in the multimodality treatment of cancer. Recent advances in RT have primarily involved improvements in dose delivery. Future improvements in tumor control and disease outcomes will likely involve the combination of RT with targeted therapies. Preclinical evaluations of angiogenesis inhibitors in combination with RT have yielded promising results with increased tumor “cure.” It remains to be seen whether these improvements in tumor control in the laboratory will translate into improved outcomes in the clinic. Multiple differences between these agents and cytotoxic chemotherapy must be taken into account when designing clinical trials evaluating their effectiveness in combination with RT. We discuss important considerations for designing clinical trials of angiogenesis inhibitors with RT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 64, Issue 1, 1 January 2006, Pages 15-25
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 64, Issue 1, 1 January 2006, Pages 15-25
نویسندگان
Deborah M.D., Cynthia M.D., Kevin M.D.,