کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8247995 1533317 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
16Oxygen irradiation enhances cued fear memory in B6D2F1 mice
موضوعات مرتبط
مهندسی و علوم پایه علوم زمین و سیارات علوم فضا و نجوم
پیش نمایش صفحه اول مقاله
16Oxygen irradiation enhances cued fear memory in B6D2F1 mice
چکیده انگلیسی
The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16O ion exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences in Space Research - Volume 7, November 2015, Pages 61-65
نویسندگان
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