کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262116 | 1534831 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training](/preview/png/8262116.png)
چکیده انگلیسی
Recent evidence suggests that the anti-inflammatory heat shock response (HSR) is reduced in aging and diabetes. In this study we compared HSR between healthy middle-aged adults, healthy elderly and type 2 diabetic (T2DM) elderly, and tested whether resistance training (RT) could improve the HSR in T2DM group. Thirty sedentary participants volunteered for this study. HSR (assessed as the capacity to export HSP72 during heat stress) was measured in the blood and compared between the groups. HSR was similar between healthy middle-aged and healthy elderly volunteers, but diminished in elderly T2DM (pâ¯<â¯0.001). Hence, T2DM subjects (nâ¯=â¯12) were submitted to a 12-week RT program, because exercise is a physiological HSR inducer. HSR, cytokines, metabolic parameters and visceral adipose tissue (VAT) were measured before and after the RT. Remarkably, VAT was negatively correlated with HSR (râ¯=â¯â 0.49, pâ¯<â¯0.01) while RT improved the HSR and reduced inflammation [TNF-α: from 51.5â¯Â±â¯9 to 40.7â¯Â±â¯4â¯pg/mL and TNF-α/IL-10 ratio: from 1.55â¯Â±â¯0.3 to 1.16â¯Â±â¯0.2 (pâ¯<â¯0.001)], without affecting other parameters. All together, these findings confirm the hypothesis that the anti-inflammatory HSR is depressed in elderly diabetic people, but can be partially restored by RT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 111, 1 October 2018, Pages 180-187
Journal: Experimental Gerontology - Volume 111, 1 October 2018, Pages 180-187
نویسندگان
Carlos Henrique de Lemos Muller, Anderson Rech, CÃntia Ehlers Botton, Helena Trevisan Schroeder, Patricia Martins Bock, Juliano Boufleur Farinha, Pedro Lopez, Cinthia Maria Schöler, Gisele Bettú Grigolo, Jerônimo Coelho, Lucas Stahlhöfer Kowalewski,