کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262386 | 1534836 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterizing age-related decline of recognition memory and brain activation profile in mice
ترجمه فارسی عنوان
مشخص کردن کاهش سن در حافظه تشخیص و مشخصات فعال سازی مغز در موش
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Episodic memory decline is one of the earlier deficits occurring during normal aging in humans. The question of spatial versus non-spatial sensitivity to age-related memory decline is of importance for a full understanding of these changes. Here, we characterized the effect of normal aging on both non-spatial (object) and spatial (object location) memory performances as well as on associated neuronal activation in mice. Novel-object (NOR) and object-location (OLR) recognition tests, respectively assessing the identity and spatial features of object memory, were examined at different ages. We show that memory performances in both tests were altered by aging as early as 15â¯months of age: NOR memory was partially impaired whereas OLR memory was found to be fully disrupted at 15â¯months of age. Brain activation profiles were assessed for both tests using immunohistochemical detection of c-Fos (neuronal activation marker) in 3and 15â¯month-old mice. Normal performances in NOR task by 3â¯month-old mice were associated to an activation of the hippocampus and a trend towards an activation in the perirhinal cortex, in a way that did significantly differ with 15â¯month-old mice. During OLR task, brain activation took place in the hippocampus in 3â¯month-old but not significantly in 15â¯month-old mice, which were fully impaired at this task. These differential alterations of the object- and object-location recognition memory may be linked to differential alteration of the neuronal networks supporting these tasks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 222-231
Journal: Experimental Gerontology - Volume 106, June 2018, Pages 222-231
نویسندگان
Hassina Belblidia, Marianne Leger, Abdelouadoud Abdelmalek, Anne Quiedeville, Floriane Calocer, Michel Boulouard, Christelle Jozet-Alves, Thomas Freret, Pascale Schumann-Bard,