کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8263194 | 1534870 | 2015 | 64 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Red blood cells open promising avenues for longitudinal studies of ageing in laboratory, non-model and wild animals
ترجمه فارسی عنوان
سلول های سرطانی سرطان پروستات امیدوار کننده برای مطالعات طولی پیری در آزمایشگاه، غیر مدل و حیوانات وحشی هستند
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کلمات کلیدی
اریتروسیت، زناشویی، استرس اکسیداتیو، گلیسیری، غشاء، تلومر، میتوکندریا،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Ageing is characterized by a progressive deterioration of multiple physiological and molecular pathways, which impair organismal performance and increase risks of death with advancing age. Hence, ageing studies must identify physiological and molecular pathways that show signs of age-related deterioration, and test their association with the risk of death and longevity. This approach necessitates longitudinal sampling of the same individuals, and therefore requires a minimally invasive sampling technique that provides access to the larger spectrum of physiological and molecular pathways that are putatively associated with ageing. The present paper underlines the interest in using red blood cells (RBCs) as a promising target for longitudinal studies of ageing in vertebrates. RBCs provide valuable information on the following six pathways: cell maintenance and turnover (RBC number, size, and heterogeneity), glucose homeostasis (RBC glycated haemoglobin), oxidative stress parameters, membrane composition and integrity, mitochondrial functioning, and telomere dynamics. The last two pathways are specific to RBCs of non-mammalian species, which possess a nucleus and functional mitochondria. We present the current knowledge about RBCs and age-dependent changes in these pathways in non-model and wild species that are especially suitable to address questions related to ageing using longitudinal studies. We discuss how the different pathways relate with survival and lifespan and give information on their genetic and environmental determinants to appraise their evolutionary potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 71, November 2015, Pages 118-134
Journal: Experimental Gerontology - Volume 71, November 2015, Pages 118-134
نویسندگان
Antoine Stier, Sophie Reichert, Francois Criscuolo, Pierre Bize,