کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8264274 | 1534885 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats
ترجمه فارسی عنوان
اولتراسونیک میتوکندریایی و نشانگرهای پویایی در هپاتوسیت ها از موش های سالم محدود شده با کالری تغذیه شده با چربی های مختلف رژیم غذایی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
محدودیت کالری، رژیم چاقی، هپاتوسیت، میتوکندریا، موش بالغ / پیر ساله،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
In this paper we analyzed changes in hepatocyte mitochondrial mass and ultrastructure as well as in mitochondrial markers of fission/fusion and biogenesis in mice subjected to 40% calorie restriction (CR) for 18Â months versus ad libitum-fed controls. Animals subjected to CR were separated into three groups with different dietary fats: soybean oil (also in controls), fish oil and lard. Therefore, the effect of the dietary fat under CR was studied as well. Our results show that CR induced changes in hepatocyte and mitochondrial size, in the volume fraction occupied by mitochondria, and in the number of mitochondria per hepatocyte. Also, mean number of mitochondrial cristae and lengths were significantly higher in all CR groups compared with controls. Finally, CR had no remarkable effects on the expression levels of fission and fusion protein markers. However, considerable differences in many of these parameters were found when comparing the CR groups, supporting the idea that dietary fat plays a relevant role in the modulation of CR effects in aged mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 56, August 2014, Pages 77-88
Journal: Experimental Gerontology - Volume 56, August 2014, Pages 77-88
نویسندگان
Husam Khraiwesh, José A. López-DomÃnguez, LucÃa Fernández del RÃo, Elena Gutierrez-Casado, Guillermo López-Lluch, Plácido Navas, Rafael de Cabo, Jon J. Ramsey, MarÃa I. Burón, José M. Villalba, José A. González-Reyes,