کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8267927 | 1534948 | 2016 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling](/preview/png/8267927.png)
چکیده انگلیسی
In this study, the hepatic effects of a discontinued PPAR-pan agonist (a triple agonist of PPAR-α, -γ, and -δ), was investigated after dietary treatment of male Sprague-Dawley (SD) rats. The agonist induced liver enlargement in conjunction with metabolomic and lipidomic remodelling. Increased concentrations of several metabolites related to processes of oxidation, such as oxo-methionine, methyl-cytosine and adenosyl-methionine indicated increased stress and immune status. These changes are reflected in lipidomic changes, and increased energy demands as determined by free fatty acid (decreased 18:3 nâ3, 20:5 nâ3 and increased ratios of nâ6/nâ3 fatty acids) triacylglycerol, phospholipid (decreased and increased bulk changes respectively) and eicosanoid content (increases in PGB2 and 15-deoxy PGJ2). We conclude that the investigated PPAR agonist, GW625019, induces liver enlargement, accompanied by lipidomic remodelling, oxidative stress and increases in several pro-inflammatory eicosanoids. This suggests that such pathways should be monitored in the drug development process and also outline how PPAR agonists induce liver proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 95, June 2016, Pages 357-368
Journal: Free Radical Biology and Medicine - Volume 95, June 2016, Pages 357-368
نویسندگان
Zsuzsanna Ament, James A. West, Elizabeth Stanley, Tom Ashmore, Lee D. Roberts, Jayne Wright, Andrew W. Nicholls, Julian L. Griffin,