کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8269544 | 1534964 | 2015 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans](/preview/png/8269544.png)
چکیده انگلیسی
Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial dysfunction is through a retrograde transcriptional reprogramming response. In this review, we primarily focus on the work that has been performed in Caenorhabditis elegans to elucidate these mechanisms. We describe several transcription factors that participate in mitochondria-to-nucleus signaling and discuss how they mediate the relationship between mitochondrial dysfunction and life span.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 78, January 2015, Pages 168-178
Journal: Free Radical Biology and Medicine - Volume 78, January 2015, Pages 168-178
نویسندگان
Hsin-Wen Chang, Ludmila Shtessel, Siu Sylvia Lee,