An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach

Venn diagram showing proteomics identified brain proteins of differential levels in Down syndrome (DS) and DS plus Alzheimer disease (DSAD) compared to their respective young controls (YCTR) and older controls (OCTR) and compared to each other. Comparison of YCTR to OCTR revealed age-related changes. New insights into mechanisms engaged prior to after development of AD neuropathology have emerged204