Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

► Brain iron dyshomeostasis in PD is an essential factor in the disease pathology. ► Brain iron accumulation involves an increase in iron-containing molecules. ► Iron induces oxidative stress. ► Iron induces α-synuclein aggregation and accumulation. ► Natural and chimeric iron chelators display potential benefits in PD animal models.