Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

► We examine mitochondrial function and neuronal excitability in human and experimental models of temporal lobe epilepsy. ► Mitochondria contribute to seizure-induced reactive oxygen species formation. ► More work is needed to determine the mechanisms of how reactive oxygen species contribute to epileptogenesis. ► We examine potential metabolic therapies and targets for epileptogenesis.