Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers

► Treatment options for neutrophilic airway inflammation are limited. ► Inhaled LPS challenge is used to study neutrophil-predominant airway inflammation. ► Gamma Tocopherol, γT, is a candidate targeting neutrophilic inflammation. ► Oral γT supplementation reduced LPS-induced airway neutrophils in rats and humans.