Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice

► Tadalafil protects against myocardial ischemia/reperfusion injury in diabetic mice. ► NADPH oxidase activity in the diabetic myocardium is attenuated by PDE-5 inhibition. ► Tadalafil attenuates reactive oxygen species generation and preserves Δψm in isolated cardiomyocytes. ► We report that tadalafil treatment attenuates oxidative stress in diabetic hearts.