Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

► Lipophilic conjugates greatly enhance the neuroprotective capacity of DFOB. ► They are more protective against iron-mediated paraquat and H2O2 toxicity in neuronal cells. ► They are more protective in iron-loaded, GSH-depleted, or A30P-α-synuclein-expressing cells.