4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart

► 4-Hydroxynonenal (HNE) catabolism is inhibited in ischemic rat heart and by exogenous fatty acids. ► Altered β oxidation regulates HNE catabolism. ► Inhibited catabolism of HNE increases protein modification.