Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing

► Aim to study the role of rare functional variants in human longevity. ► Implementation of target capture and next-generation sequencing. ► Comprehensive analysis of 988 candidate genes for discovery of novel nsSNPs. ► Identification of GABRR3 and PMS2 as potential longevity-associated genes.