کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8285055 | 1535619 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of candidate ocular biomarkers of ageing in a South African adult population: Relationship with chronological age and systemic biomarkers
ترجمه فارسی عنوان
ارزیابی بیومارکرهای نامزدی چشم سالم در بزرگسالان بالغ در آفریقای جنوبی: رابطه با سن زمانی و بیومارکرهای سیستمیک
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Certain anatomic and functional parameters of the eye change with increasing chronological age. They may, therefore, serve as potential biomarkers of ageing. We investigated associations between four such ocular parameters (lens density, retinal vessel calibre, corneal endothelial cells and retinal nerve fibre layer thickness) and two 'cellular' biomarkers of ageing (leukocyte telomere length and CDKN2A expression), with frailty (a clinical correlate of biological ageing) in a population of South African adults. All ocular parameters revealed an association with either telomere length or CDKN2A expression. However, lens density was most strongly correlated with age, increased CDKN2A expression, and with frailty (p = 0.05 and 0.03, respectively). Narrow retinal arteriolar diameter, associated with increased chronological age, was also associated with increased CDK2NA expression (0.42 vs. 0.31, p = 0.02) but not with frailty. Ocular parameters may aid in determining biological age, warranting investigation in longitudinal studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 134, Issues 7â8, JulyâAugust 2013, Pages 338-345
Journal: Mechanisms of Ageing and Development - Volume 134, Issues 7â8, JulyâAugust 2013, Pages 338-345
نویسندگان
Sophia Pathai, Clare E. Gilbert, Stephen D. Lawn, Helen A. Weiss, Tunde Peto, Colin Cook, Tien Y. Wong, Paul G. Shiels,