Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease

► The capacity of apoA-I and HDL to mediate cholesterol efflux is altered in Alzheimer's disease. ► This alteration is correlated with the severity of the cognitive decline. ► Alzheimer's disease-associated oxidative stress and inflammatory conditions induce an impairment of the HDL functionality.