Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals

► 3 months-continuous environmental enrichment improves cognitive abilities in adult female NMRI mice, including learning and memory. ► Behavioral improvement is not correlated with changes in the expression of synaptic plasticity within neuronal networks, such as theta burst-induced LTP. ► Environmental enrichment delivered in aged NMRI mice at middle life span does not rescue age-related deficits of learning and memory.