LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects

▶ LSP mediated production of inflammatory mediators was induced in 50 WBA samples. ▶ Significantly different were their levels in the 50 samples screened for TLR4 SNP. ▶ Proinflammatory cytokines and eicosanoids were significantly lower in the carriers. ▶ In contrast, their antiinflammatory IL-10 values were higher. ▶ So, the biological effect of TLR4 SNP is an adequate control of inflammatory responses.