کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8288043 | 1535874 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PLC and PI3K/Akt/mTOR signalling in disease and cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PLC and PI3K/Akt/mTOR signalling in disease and cancer PLC and PI3K/Akt/mTOR signalling in disease and cancer](/preview/png/8288043.png)
چکیده انگلیسی
Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Biological Regulation - Volume 57, January 2015, Pages 10-16
Journal: Advances in Biological Regulation - Volume 57, January 2015, Pages 10-16
نویسندگان
Matilde Y. Follo, Lucia Manzoli, Alessandro Poli, James A. McCubrey, Lucio Cocco,