کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8289191 1536300 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Switching of actin-myosin motors by voltage-induced pH bias in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Switching of actin-myosin motors by voltage-induced pH bias in vitro
چکیده انگلیسی
ATP-driven motor proteins, which function in cell motility and organelle transport, have potential applications as bio-inspired micro-devices; however, their control remains unsatisfactory. Here, we show rapid-velocity control of actin filaments interacting with myosin motors using voltage applied to Pt electrodes in an in vitro motility system, by which immediate increases and decreases in velocity were induced beside the cathode and anode, respectively. Indicator dye revealed pH changes after voltage application, and alternate voltage switching allowed actin filaments to cyclically alter their velocity in response to these changes. This principle provides a basis for on-demand control of not only motor proteins but also pH-sensitive events at a microscopic level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 603, 1 August 2016, Pages 64-71
نویسندگان
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