کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8289285 | 1536302 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes](/preview/png/8289285.png)
چکیده انگلیسی
Graphic representation of hypothesis and results. We tested the hypothesis that the LKB1 complex associated with myofilament proteins in the sarcomere and altered this association with energy stress. In general, creatine kinase (CK) and adenylate kinase (AK) balance the available ATÂ =Â P for use by the contractile proteins, specifically myosin. Pathological energy stress from FHC or CVD elevates myofibrillar AMP that recruits LKB1 and AMPK complex proteins to myofibrils. LKB1 activates AMPK in the presence of elevated AMP, which directly impacts myofilament function.320
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 601, 1 July 2016, Pages 32-41
Journal: Archives of Biochemistry and Biophysics - Volume 601, 1 July 2016, Pages 32-41
نویسندگان
Samantha M. Behunin, Marissa A. Lopez-Pier, Rachel M. Mayfield, Christiane A. Danilo, Yulia Lipovka, Camille Birch, Sarah Lehman, Jil C. Tardiff, Carol C. Gregorio, John P. Konhilas,