Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain

- Sub-micellar SDS concentration rapidly induces fibrillization of SB at pH 2.0.
- Bis-ANS is about 3-fold more potent inhibitor of SB fibrillation than ANS.
- H-bonding and π-π interactions are evident in binding of ANS and bis-ANS to SB.
- Ionic interactions play negligible role in binding of naphthalene derivatives to SB.
- Inhibition may be due to disrupted π-π interactions and inter-polypeptide repulsion.