Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle

► Rutin stimulates calcium uptake in soleus muscle. ► L-VDCC, CaMKII, MEK and PKA are involved in the signaling pathways of rutin. ► Calcium influences the stimulatory effect of rutin on DNA activity. ► Rutin induced-glucose uptake through CaMKII in soleus muscle.