Oncogenic Ras suppresses Cdk1 in a complex manner during the incubation of activated Xenopus egg extracts

► We study how oncogenic Ras suppresses Cdk1. ► Oncogenic Ras suppresses Cdk1 via induction of persistent inhibitory phosphorylation of Cdk1. ► Oncogenic Ras stabilizes cyclin B2. ► The stabilization of cyclin B2 is mediated by the Raf-Mek-Erk-p90rsk pathway. ► Our results indicate that oncogenic Ras suppresses Cdk1 in a complex manner.