Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration

► PDGF-BB stimulates the activation of AMPK in a VSMC line, A10 cells. ► PDGF-BB-induced A10 cell migration is suppressed by AMPK inhibitor or AMPK-α siRNA. ► AMPK regulates the p44/p42 MAP kinase pathway and the PI3-kinase/Akt pathway. ► AMPK is implicated in PDGF-BB-induced VSMCs migration.