Correlation between CD16a binding and immuno effector functionality of an antigen specific immunoglobulin Fc fragment (Fcab)

► CD16a binding and ADCC functionality of a Her-2 binding binding Fc (Fcab) are shown to correlate. ► Point mutations known to influence ADCC efficiency in mAbs lead to similar changes in Fcabs. ► Fcabs can be engineered to fine tune immuno effector functions.