Isotype and glycoform selection for antibody therapeutics

► Human IgG is comprised of four subclasses and multiple heavy and kappa chain allotypes. ► Immune protection is afforded by immune complex activation of inflammatory cascades. ► Inflammatory cascades are activated through IgG-Fc receptors and complement C1q. ► The glycoform of IgG antibodies influences IgG-Fc receptor and C1q activation. ► The long catabolic half life is independent of normal glycoforms.