Fungal catalases: Function, phylogenetic origin and structure

► An ancient HGT of a large subunit catalase gene from Actinobacteria to fungi. ► A recent HGT of a large subunit catalase gene from bacteria to Malassezia globosa. ► Clade-1 heme orientation and NADPH binding site in a group of fungal catalases. ► Only one forth of fungal small catalases has a signal for peroxisomal localization. ► Molecular dynamics simulation shows opening of catalase major channel bottleneck.