Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

► We model renal ischemia-reperfusion injury in LLC-PK1 cells. ► We study the viability changes to compounds of LOPAC library. ► Adenosine exerts protection against oxygen-glucose deprivation injury. ► Adenosine receptors do not participate in the protective effect of adenosine. ► Adenosine kinase and adenosine deaminase play important roles in the cytoprotection.