Effect of 1α,25-dihydroxyvitamin D3 in plasma membrane targets in immature rat testis: Ionic channels and gamma-glutamyl transpeptidase activity

► 1,25D3 stimulates Ca2+ uptake in immature rat testis. ► The Ca2+ uptake stimulated by 1,25D3 is mediated by ATP- and Ca2+-dependent K+ channels and Ca2+-dependent Cl− channels. ► The stimulatory effect of 1,25D3 on Ca2+ uptake depends on PKA, PKC and ERK1/2 pathways. ► 1,25D3 is able to increase the gamma glutamyl transpeptidase activity.