AMP-activated protein kinase modulates the gene expression of aquaporin 9 via forkhead box a2

► Transcriptional regulation of the AQP9 gene by activated AMPK. ► Suppressed expression of the AQP9 gene by AICAR. ► Phosphorylations of AMPK, Akt and Foxa2 by AICAR. ► Promotion of nuclear export of Foxa2 by AICAR and prevention by leptomycin B. ► AMPK modulates the expression of the AQP9 gene via Foxa2.