Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: Studies on the formation of catalytically non-productive enzyme complexes

► Non-productive ternary complexes in the substrate inhibition seen with hSULT2A1. ► hSULT2A1-PAP-DHEA complex is a major component of substrate inhibition. ► Negative cooperativity seen in the binding of dehydroepiandrosterone to hSULT2A1.