1,25-Dihydroxyvitamin D3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation

► Vitamin D suppresses LPS- or TNFα- induced PAI-1 expression. ► A functional cis-κB element is identified in the mouse PAI-1 gene promoter. ► NF-κB mediates the stimulatory effect of LPS and TNFα on PAI-1. ► Vitamin D suppresses PAI-1 up-regulation via blocking NF-κB activation.