کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8298616 1537035 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2
چکیده انگلیسی
Analysis of steady-state levels of COX subunits and of assembly intermediates by Blue-Native gels shows a pattern similar to that reported in cells lacking COX18, suggesting that COX16 is required for the formation of the COX2 subassembly module. Moreover, COX16 co-immunoprecipitates with COX2. Finally, we found that copper supplementation increases COX activity and restores normal steady state levels of COX subunits in COX16 knockout cells, indicating that, even in the absence of a canonical copper binding motif, COX16 could be involved in copper delivery to COX2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1859, Issue 4, April 2018, Pages 244-252
نویسندگان
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